Now that Avatar has had two unbelievable weekends and is now in its third, it is time to start talking about a second one. Thank you Internet. The most recent interesting rumor involves the location of any further films. The blog Market Saw claims to have confirmation that the next films will not take place on Pandora, as this one did.
Their support seems to be coming from a round-table that director James Cameron was a part of. In response to a question about the moons seen in the film and their roles in the future, Cameron said,
The planet in Pandora's sky, is called Polyphemus and it's the primary for the system of moons just like in our solar system." Adding, "We have some story ideas about how to branch out into other moons of the Polyphemus and the Alpha Centauri A solar system.
Not quite the confirmation they tout. Also, is it surprising that future installments of the franchise wouldn't take place in the same location? The film based a lot of itself on its visuals, and under those circumstances, they certainly wouldn't want to leave those visuals the same. You have to change what people see to keep the interested, and moving to another moon is a great way to keep the characters while changing the scenes.
The good news here is that Cameron hasn't placed the basis of the story in the basic environment (like Star Trek has been known for). The fact that the planet, and possibly other moons, already have names and seemingly back stories, this will not be the classic Matrix-style crappy money-grubbing sequels.